Priority strategies to optimize
testing and quarantine at
Canadas borders
Health Canada is responsible for helping Canadians maintain and improve their health. It ensures that high-quality
health services are accessible, and works to reduce health risks.
Également disponible en français sous le titre :
Stratégies prioritaires pour optimiser les tests et le dépistage dans les foyers de soins de longue durée
To obtain additional information, please contact:
Health Canada
Address Locator 0900C2
Ottawa, ON K1A 0K9
Tel.: 613-957-2991
Toll free: 1-866-225-0709
Fax: 613-941-5366
TTY: 1-800-465-7735
E-mail: hc.publications-publicat[email protected]
© Her Majesty the Queen in Right of Canada, as represented by the Minister of Health, 2021
Publication date: May 2021
This publication may be reproduced for personal or internal use only without permission provided the source is
fully acknowledged.
Cat.: H14-360/2021E-PDF
ISBN: 978-0-660-38316-3
Pub.: 210027
| i
Priority strategies to optimize testing and quarantine at Canada’s borders
Executive summary
In November 2020, the Minister of Health established the COVID-19 Testing and Screening Expert Advisory Panel.
The Panel provides evidence-informed advice to the federal government on science and policy related to existing
and innovative approaches to testing and screening.
The Panel has issued 3 reports since January 2021. This fourth report provides recommendations for land and air
border measures. The Panel did not include marine border measures in its scope of analysis or recommendations.
Border measures help to reduce risk. They’re designed to:
reduce mortality and morbidity from COVID-19 by limiting the introduction of SARS-CoV-2 and emerging
variants of concern (VoCs) into Canada
maintain essential supply chains and services and ensure that travel restrictions are not excessive to
public health needs
use surveillance of SARS-CoV-2 and VoCs at the borders for all types of travellers to inform ongoing
measures
The advice in this report may require revision both due to rapidly evolving evidence and the continued evolution of
the pandemic. The Panel is providing this advice as a third wave of COVID-19 is occurring in much of the country.
As such, the report assumes that the current federal recommendations against non-essential travel will remain in
force. The Panel emphasizes the need for Canadians, including vaccinated travellers, to follow public health
requirements such as physical distancing and mask wearing. The Panel also emphasizes that all individuals with
symptoms of COVID-19 should be tested using a PCR test. Finally, the Panel notes that the role of border measures
is to mitigate risk, recognizing that it’s impossible to eliminate risk completely given the need to maintain essential
supply chains and services.
Our recommendations apply to people entering Canada from other countries. Whether vaccinated or not,
travellers entering other countries may be subject to different quarantine and testing requirements. Similarly,
while the Panel recommends consistency across the country, we recognize that those entering Canada may face
additional requirements or restrictions in some provinces or territories.
The Panel considered 3 broad principles in developing its recommendations:
1. Border measures must evolve to reflect the experience gained and the global situation regarding VoCs
and vaccination
The Government of Canada should continue to screen positive cases among international
travellers for VoCs.
Additional short-term measures may be necessary as and when emerging VoCs are identified in
Canada or internationally.
The Government of Canada have procedures in place to ensure that all travellers submit required
tests and that all positive results are immediately communicated to the appropriate local health
authority.
2. Border measures must be simple, easy to understand, equitable and consider both benefits and harms
The current requirement for all air travellers to quarantine in government-authorized
accommodations should be discontinued. However, travellers subject to quarantine must
provide a suitable quarantine plan for approval and then adhere to this plan. If the traveller does
not have a suitable quarantine plan, they should be required to adhere to an alternative one (for
example, in designated quarantine facilities).
ii |
Priority strategies to optimize testing and quarantine at Canada’s borders
Testing requirements that vary by country of origin should not be implemented for travellers
entering Canada except under unique circumstances. Increased monitoring of quarantine
compliance should be considered for travellers arriving from countries with new variants of
concern.
As much as possible, land and air border measures should be consistent.
There is no substantial incremental value in additional testing for people travelling to other
Canadian destinations once they have arrived at their first port of entry in Canada, considering
they will be going through other testing points.
3. Changes to border measures should be implemented in stages
Implementation of new border measures should be phased in, as the implementation process,
including enforcement, may take time to put in place.
The federal government should continue to use the ArriveCAN app for traveller information
reporting. The government should also review/approve quarantine plans for all arriving travellers
at both land and air borders, including screening for symptoms for all travellers.
There should be a system in place to validate proof of vaccination for arriving travellers as soon
as possible.
The Panel identified 5 distinct groups of travellers:
non-exempt who are not vaccinated
partially vaccinated (received the first dose of a 2-dose series, are within the recommended maximum
interval period between doses and 14 days have passed since the first dose)
fully vaccinated (14 days have passed since the final dose)
non-exempt with proof of previous infection
exempt as defined by the Government of Canada, such as essential workers
Along with recommending that all travellers follow public health requirements (including physical distancing, mask
wearing), the Panel offers the following recommendations for each type of traveller:
For unvaccinated non-exempt travellers:
pre-departure polymerase chain reaction (PCR) test within 72 hours of departure or an
authorized rapid antigen test within 24 hours of departure
PCR test on arrival at the border testing station or the quarantine location (for land border
crossing, a home-sampling kit may be used)
travellers with a negative PCR test result taken at day 7 of quarantine to be permitted to leave
quarantine, those with a positive result to isolate according to public health guidance and those
who do not take a day 7 test to complete 14 days of quarantine
For partially vaccinated non-exempt travellers:
pre-departure PCR test within 72 hours of departure or an authorized rapid antigen test within
24 hours of departure
PCR test on arrival at the border testing station or the quarantine location (for land border
crossing, a home-sampling kit may be used)
travellers with a negative PCR test taken on arrival to be permitted to leave quarantine and those
with a positive result to isolate according to public health guidance
For fully vaccinated non-exempt travellers:
acceptable proof, as defined by the Government of Canada, of authorized vaccination and that
sufficient time has passed after the final dose in the vaccine series
no pre-departure test, quarantine requirement or day 7 test
for surveillance purposes, PCR test on arrival at the border testing station (for land border
crossing, a home-sampling kit may be used)
| iii
Priority strategies to optimize testing and quarantine at Canada’s borders
For travellers with proof of previously resolved infection (more than 14 days but less than 180 days before
the travel day):
acceptable proof, as defined by the Government of Canada, of infection within this time period
PCR test on arrival at the border testing station or the quarantine location (for land border
crossing, a home-sampling kit may be used)
travellers with a negative PCR test taken on arrival to be permitted to leave quarantine and those
with a positive result to continue to isolate according to public health guidance.
For all exempt travellers:
voluntary arrival testing using lab-based PCR or rapid tests with sample collection completed
away from the border (ideally implemented to allow for robust surveillance, to provide
information on further potential recommendations for this group)
| v
Priority strategies to optimize testing and quarantine at Canada’s borders
Table of contents
Executive summary ................................................................................................................................................. i
Table of contents ................................................................................................................................................... v
The Expert Advisory Panel and reports .................................................................................................................. 1
Mandate of the Panel ................................................................................................................................................ 1
Plan for reports ......................................................................................................................................................... 1
Consultation .............................................................................................................................................................. 1
Guiding principles ...................................................................................................................................................... 1
Terms ......................................................................................................................................................................... 1
Acknowledgements ................................................................................................................................................... 2
Objectives of border measures .............................................................................................................................. 3
Background ............................................................................................................................................................ 5
Evidence ................................................................................................................................................................ 7
Pre-departure and arrival testing .............................................................................................................................. 7
Testing to exit quarantine ......................................................................................................................................... 8
Mandatory quarantine approaches .......................................................................................................................... 8
Exempt travelers ..................................................................................................................................................... 10
Onward travellers .................................................................................................................................................... 10
Vaccinated travellers ............................................................................................................................................... 11
Recommendations ............................................................................................................................................... 15
Border measures must evolve to reflect the experience gained and the global situation regarding VoCs and
vaccination .............................................................................................................................................................. 15
Border measures must be simple, easy to understand, equitable and consider both benefits and harms ........... 15
Changes to border measures should be implemented in a phased approach ........................................................ 16
Implementation considerations ........................................................................................................................... 21
Surveillance system characteristics ......................................................................................................................... 21
Border logistics ........................................................................................................................................................ 21
Quarantine and testing capacity ............................................................................................................................. 21
New testing tools .................................................................................................................................................... 21
Digital technology .................................................................................................................................................... 22
Communication ....................................................................................................................................................... 22
Further evolution of border measures .................................................................................................................... 22
Conclusion ........................................................................................................................................................... 23
Annex A: Summary of current border measures for persons entering Canada ..................................................... 25
Annex B: Exempt travelers ................................................................................................................................... 27
References ........................................................................................................................................................... 29
| 1
Priority strategies to optimize testing and quarantine at Canada’s borders
The Expert Advisory Panel and reports
Mandate of the Panel
The COVID-19 Testing and Screening Expert Advisory Panel aims to provide timely and relevant guidance to the
Minister of Health on COVID-19 testing and screening.
The Panel’s mandate is to complement, not replace, evolving regulatory and clinical guidance on testing and
screening. Our reports reflect federal, provincial and territorial needs, as all governments seek opportunities to
integrate new technologies and approaches into their COVID-19 response plans.
Plan for reports
The focus of the first Panel report included 4 immediate actions to optimize testing and screening:
1. optimize diagnostic capacity with lab-based PCR testing
2. accelerate the use of rapid tests, primarily for screening
3. address equity considerations for testing and screening programs
4. improve communications strategies to enhance testing and screening uptake
The second report focused on testing and screening strategies in the long-term care sector. The third report
provided a perspective on how the recommendations from the first report can be applied to schools. This fourth
report focuses on testing and quarantine measures for Canada’s borders.
Consultation
The Panel consulted with more than 60 health, public policy, border and transportation experts, as well as other
industry stakeholders who are impacted by the COVID-19 border measures. The Panel will continue to consult with
a variety of stakeholders as we prepare further reports.
Guiding principles
Public health initiatives should minimize unintended harm, promote equity and increase transparency and
accountability. Panel discussions and engagement with stakeholders highlighted a number of key principles to
consider in its guidance, including equity, feasibility and acceptability. The Panel applied these principles in framing
its guidance.
This report contains the Panel's independent advice and recommendations, which were based on available
information at the time of writing the report. The Panel examined scientific journal articles, modeling studies,
news articles and data from the Public Health Agency of Canada to inform its recommendations.
Terms
Some of the terms used in the report may not be familiar to all readers. Key terms used in this report include:
Vaccinated: People who have received both doses of a 2-dose authorized vaccine or 1 dose of a single-
dose authorized vaccine and 14 days have passed since the final dose.
Partially vaccinated: People who received the first dose of a 2-dose authorized vaccine at least 14 days
ago and are within the recommended maximum interval period between doses.
2 |
Priority strategies to optimize testing and quarantine at Canada’s borders
Unvaccinated: People who have not received a dose of a COVID-19 vaccine or those with a single dose of
a 2-dose COVID-19 vaccine and the recommended maximum 2-dose interval period has passed
Acknowledgements
The Panel expresses its appreciation to the ex officio members of the Panel and to officials at Health Canada who
have been working tirelessly to support the Panel. The Panel also acknowledges the contributions of the "shadow
panel" on testing and screening, a group of students and young scientists who provided expert research and
analytical assistance. Shadow panel members include Rahul Arora, Matthew Downer, Jane Cooper, Michael Liu,
Jason Morgenstern, Netra Unni Rajesh, Sara Rotenberg and Tingting Yan.
Sue Paish, Co-Chair
Dr. Irfan Dhalla, Co-Chair
Panel members:
Dr. Isaac Bogoch
Dr. Mel Krajden
Dr. Jean Longtin
Dr. Kieran Moore
Dr. David Naylor
Mr. Domenic Pilla
Dr. Udo Schüklenk
Dr. Brenda Wilson
Dr. Verna Yiu
Dr. Jennifer Zelmer
| 3
Priority strategies to optimize testing and quarantine at Canada’s borders
Objectives of border measures
Border measures serve to reduce risk but not eliminate it through measures, including testing and quarantine,
which are intended to:
reduce mortality and morbidity from COVID-19 by limiting the introduction of SARS-CoV-2 and its VoCs
into Canada
maintain essential supply chains and services and ensure that travel restrictions are not excessive, while
continuing to protect the public
use surveillance testing of SARS-CoV-2 and VoCs at the borders for travellers, including voluntary testing
of exempt travellers, to inform ongoing measures
This report presents the Panel’s advice to the Minister of Health on border measures to be considered in relation
to the Order in Council Minimizing the Risk of Exposure to COVID-19 in Canada Order (Quarantine, Isolation and
Other Obligations).
| 5
Priority strategies to optimize testing and quarantine at Canada’s borders
Background
Canada’s border measures are informed by obligations under the International Health Regulations (IHR). The IHR is
an instrument of international law that is legally binding on 196 countries to limit the spread of health risks while
preventing unwarranted travel and trade restrictions. Recognizing the IHR, Canada cannot impose health-related
travel restrictions except in situations of public health emergencies (such as COVID-19). When doing so, Canada
must recognize the rights of travellers concerning treatment of personal data, informed consent and non-
discrimination.
Like most countries, Canada has implemented measures and placed restrictions on entry and re-entry at border
crossings during the pandemic, including mandatory quarantine. These are designed to:
reduce the importation and subsequent spread of SARS-CoV-2
decrease the volume of international travel to and from Canada
For example, international travel to and from the country declined from 96.8 million travellers in 2019 to 25.9
million in 2020. The number of travellers entering Canada decreased by over 90% from December 2019 to
December 2020.
Border measures became more stringent in 2021 to further limit the importation of SARS-CoV-2 and to create a
testing and sequencing perimeter to better respond to variants of concern (VoCs). These measures (see Annex A)
included requiring:
a negative SARS-CoV-2 PCR test before and/or on arrival to Canada
a brief quarantine at a hotel or another approved location such as a traveller’s home
another test before the end of the quarantine period
There was a decrease of 41% in the rate of imported cases of COVID-19 from early January (152 cases per 100,000
arrivals) to early March (90 cases per 100,000 arrivals). In February, Canada further required air travellers to
quarantine in government-authorized accommodations while awaiting arrival test results.
From February 21 to March 24, 1.3% of non-exempt travellers tested positive on arrival and 1% tested positive on
day 10. However, there is not enough information to understand how many chains of transmission were initiated
by these travellers and what contribution travel makes to the overall burden of disease in Canada at this time.
Some travellers are exempt from COVID-19 testing and quarantine measures because they provide essential
services (see Annex B). Additional measures for this group could impose undue hardship and adversely impact
essential services. From December 2020 to March 2021, most travellers (88% to 93%) entering Canada by land
were exempt from testing and quarantine requirements (for example, truck drivers and health care workers).
During this period, those entering Canada by air were primarily non-exempt travellers (65% to 86%) and were
required to follow testing and quarantine requirements.
In Canada, all positive samples identified through border measures are sent for genetic sequencing to confirm and
identify any VoCs. From February 22, 2021, to March 25, 2021, there were 171 VoC cases confirmed (161 cases of
B1.1.7 and 10 cases of B1.351) by sequencing of positive tests from travellers (14% of total positive cases
identified). This may be an underestimate given the delay to complete sequencing.
6 |
Priority strategies to optimize testing and quarantine at Canada’s borders
Figure 1: SARS-CoV-2 importation by method of non-exempt travel
Canada’s current border measures aim to reduce the importation and further spread of SARS-CoV-2, including
VoCs. Previous border measures were insufficient to prevent the importation of the B.1.1.7 VoC, which is now the
dominant strain in Ontario and British Columbia. As well, P.1 is gaining ground in British Columbia. It is important
to note that by the time a variant is identified as being “of concern,” it is highly likely to be present in many
countries around the world. Therefore, excessive or ‘targeted’ focus on travellers arriving from a single country is
likely to provide a false sense of reassurance and not materially impact the presence of a VoC in Canada.
The Panel notes that the necessary testing capacity and recommendations will depend on the number of travellers
and the global and domestic epidemiological situation as borders begin to reopen. Similarly, the COVID-19
situation is one of evolving risk and border measures are put in place to mitigate that risk. A regularly updated risk
assessment is critical to understanding the risk factors, as well as the impact of border measures.
Border measures also come at a cost to the economy and to the movement of Canadians. For example, airlines are
reporting operating at significantly lower capacity compared to the previous year. As the roll-out of vaccination
programs advances domestically and internationally, the volume of travel will likely increase. A new balance will
need to be found with modified testing and quarantine requirements. However, some border measures are likely
to be required for the foreseeable future.
| 7
Priority strategies to optimize testing and quarantine at Canada’s borders
Evidence
The Panel’s recommendations for border measures are based on data from the scientific literature and the Public
Health Agency of Canada and experiences to date, including modelling studies, observational studies and pilots. As
new evidence on vaccination, VoCs, border measures and other aspects of SARS-CoV-2 emerges, it will be
important to ensure that:
the goal of limiting the importation of SARS-CoV-2 and its VoCs is maintained and
the guidance in this report is reviewed and updated accordingly
The key elements of the Panel recommendations related to border measures are pre-departure testing, arrival
testing, quarantine and quarantine exit testing.
Pre-departure and arrival testing
Modelling shows that both pre-departure and arrival testing are likely to reduce importation of SARS-CoV-2, and
both types of testing are more effective when used together.
1
,
2
Pre-departure testing can reduce the number of
actively infectious individuals who arrive in Canada, and the risk of transmission is further reduced when testing is
done close to departure time (24 to 48 hours before).
3
,
4
,
5
,
6
From a logistics perspective, pre-departure testing is also less likely to result in delays at the border. Some
modelling studies suggest that pre-departure rapid antigen tests (RATs) conducted close to departure (24 hours or
less) may be as effective at identifying positive cases as PCR tests collected within 72 hours before departure
(assuming 80% to 95% sensitivity of the RAT).
7
,
8
However, estimates of the sensitivity of RATs in asymptomatic
people vary (45% to 91%).
9
,
10
,
11
,
12
When modeled with lower sensitivity, RATs for pre-departure testing are not as
effective as PCR testing when conducted within 72 hours before departure. Therefore, there remains some
uncertainty regarding the effectiveness of RATs used as pre-departure tests.
For pre-departure tests, some countries (for example, US, Haiti, Jamaica, Germany, Switzerland, Italy) will accept
RATs in lieu of PCR tests.
13
,
14
,
15
,
16
,
17
,
18
The Netherlands will accept RATs taken within 24 hours of departure, in
addition to a PCR test taken within 72 hours of departure. Iceland does not accept RATs for pre-departure testing.
Some hotels have also reportedly started offering on-site rapid tests to help with the travel testing requirement.
Two Canadian airport pilot studies and the Public Health Agency of Canada (PHAC) have collected data on the
arrival test positivity rate. The Alberta border testing pilot, which began November 2, 2020, tested 50,929 non-
exempt travellers, of which 1.37% had a positive test result upon arrival. The McMaster HealthLabs study found
that 1% of those tested on arrival were positive for COVID-19. The Alberta pilot found that the proportion of air-
travellers who tested positive within 14 days (2.2%) did not differ greatly compared to land travellers (1.9%).
While these positivity rates may seem low, it’s important to consider that these individuals were not tested
because they had symptoms or were close contacts of individuals with COVID-19. In this context, test positivity
rates of 1% to 2% support the importance of arrival testing as a means of reducing transmission, especially
potential transmission of VoCs.
PHAC data from arrival tests at both land and air borders conducted between February 22 and March 24, 2021,
found an overall arrival test positivity of 1.3%. Air travellers had an arrival test positivity rate of 1.5% while land
travellers had an arrival test positivity rate of 0.3%.
8 |
Priority strategies to optimize testing and quarantine at Canada’s borders
Testing to exit quarantine
Modelling studies indicate that a 7-day quarantine with a test at the end of the quarantine period may be similarly
effective to a 14-day quarantine without testing.
19
,
20
,
21
In terms of ‘real-world’ evidence, the McMaster HealthLabs
study found that 94% of all cases were detected by the day 7 test.
Quarantine exit testing becomes more important when compliance with quarantine is low. Depending on the level
of compliance, a 7-day quarantine with testing may be more effective than a 14-day quarantine without testing.
22
,
23
While a mandatory three-day initial quarantine in government-authorized accommodations obviously improves
compliance during those 3 days, the level of compliance after is uncertain. Requiring a test at day 7 of quarantine
to facilitate exit may prove to be an incentive and thus increase compliance, resulting in more robust surveillance.
Considerable effort is being made to ensure quarantine is observed. The federal government made 1.48 million
calls between April 2020 and March 2021. Canada also deployed local police or security contractors to do site visits
for 121,617 quarantined travellers between January 29 and March 25, 2021. Continued efforts to monitor and, if
needed, improve adherence to quarantine are warranted.
Currently, travellers are required to be tested on day 10 of their 14-day quarantine. Internal data from PHAC
suggests there are fewer day 10 tests completed compared to number of arrival tests. For example, air travellers
submitted 31,616 arrival samples for testing from February 22 to March 6, 2021. However, only 21,100 samples for
day 10 quarantine exit tests had been received by March 20.
Last, it is possible that new variants that have a longer incubation period may emerge. In this case, the length of
quarantine and timing of exit tests will both need to be revised.
International examples
United Kingdom: The United Kingdom has implemented a phased testing exit strategy for international arrivals.
Passengers must complete a passenger locator form with a travel plan and have proof of a negative PCR test
within 72 hours of departure. They undergo additional testing on days 2 and 8 at their own cost and can leave
quarantine once the day 8 test confirms a negative result. There is also an early release program in certain
regions of England, where travellers may pay for a private, government-authorized PCR test on day 5 and leave
with a confirmed negative result. Passengers cannot travel to the United Kingdom if they have been through a
country on the banned travel list unless they are British, Irish or have the right to live in the United Kingdom. If
returning from a country on this list, the traveller must quarantine for 10 days in a government-authorized
accommodation.
Germany: Travel to Germany is banned from countries where there is high prevalence of variants of concern,
except for citizens/residents, connecting travellers or other special cases. For the European Union, Schengen
and other low-risk countries, travellers must register their plans online and follow all testing and quarantine
regulations. Travellers from high-risk areas must have a negative test 48 hours before entry. While quarantine
protocols are determined by local Länders (states), in general travellers from high-risk areas must be tested
before or immediately after entering the country and then self-isolate for 10 days. In some Länders, travellers
can leave quarantine after 5 days, following a negative test result.
Mandatory quarantine approaches
Canada’s current quarantine policy requires a mandatory 3-day quarantine in a government-authorized
accommodation on arrival for non-exempt air travellers. This policy was designed to maximize compliance for the
first 3 days of the required 14-day quarantine. It also ensures that some imported cases of COVID are identified
| 9
Priority strategies to optimize testing and quarantine at Canada’s borders
and managed before the traveller moves into the community. Non-exempt travellers entering by land are not
required to quarantine in a government-authorized accommodation. Australia, which has a COVID-19 elimination
strategy, requires all travellers to quarantine for 14 days in government-authorized accommodations to reduce the
secondary transmission of COVID-19 into the community.
While likely improving quarantine compliance in Canada for the short term, there are several issues related to
mandatory government-authorized accommodation worthy of consideration. First, some travellers are choosing to
pay a fine of up to $3,000 rather than staying in a government-authorized accommodation or a designated
quarantine facility. These travellers may or may not be adhering to quarantine. Second, there are significant
administrative costs and resources devoted to managing hotel quarantine that cannot be used for other issues
related to the pandemic response. Third, travellers face an added cost (up to $2000 CAD per person), time
commitment and a burden to book government-authorized accommodation. Fourth, due to the costs and the
reality that land and air border measures do not currently align (land travellers are not required to undergo
mandatory hotel quarantine), some travellers are landing at U.S. airports and crossing into Canada by land. Fifth,
hotel quarantine of up to 3 days is inconsistent with the incubation period of SARS-CoV-2.
The costs and hardships from lengthier mandatory quarantine in government-authorized accommodations may be
acceptable in countries such as New Zealand and Australia that are pursuing an elimination strategy. Nevertheless,
the Panel noted that despite strict health measures, there have been reports of hotel quarantine workers testing
positive for SARS-CoV-2 in both Australia and New Zealand.
In Canada, the current approach to mandatory hotel quarantine:
is not applied equally to land and air travellers
is expensive to administer
provides opportunities for travellers to bypass by paying a fine
is inconsistent with the incubation period of the virus
Government-authorized accommodations also require participating hotels to implement strict public health
measures to ensure employees and visitors are not infected during their visit. This includes ensuring employees are
adequately protected and undergo frequent screening tests to minimize the risk of infection and further
community transmission.
International example
Singapore: Non-citizens require pre-clearance to travel into Singapore at least 2 weeks before travel. All
travellers must complete a Stay Home Notice, although the length (7 days or 14 days) and location of
quarantine depends on the person’s travel history and entry status. Travellers also require a PCR test within 72
hours of departure and upon arrival (at their own cost). People who have travelled to a select few countries
(Australia, Brunei Darussalam, Mainland China, New Zealand and Taiwan) are allowed to leave as soon as the
on-arrival PCR test is confirmed as negative. Singapore’s strategy has been largely successful in limiting the
number of imported cases.
In addition, currently in Canada, some jurisdictions require that travellers self-isolate in a separate dwelling from
those in the household who have not travelled.
24
,
25
If this is not possible, the entire household must self-isolate.
Given the current Canadian context, the Panel recommends a strong focus on adherence to quarantine rather than
modifying the hotel quarantine program to become more like those in place in New Zealand and Australia.
Research indicates that emphasizing quarantine as a social norm increases the perceived benefits of quarantine as
well as compliance with quarantine. Recent research also indicates that specific supports related to financial
support, temporary accommodation if necessary, clear communication, effective contact tracing and routine
10 |
Priority strategies to optimize testing and quarantine at Canada’s borders
monitoring would help to increase compliance (as opposed to enforcing a specific quarantine location).
26
,
27
The
Panel also noted that quarantine is being used to good effect in Atlantic Canada.
Exempt travelers
In Canada, some travellers are exempt from border measures (see Annex B), which is similar to other countries
such as the United States. In Canada, due to a dramatic decrease in non-exempt travel, exempt travellers currently
make up a large proportion of current travellers. For instance, between March 10 and 16, 2021, exempt travellers
comprised 31% of all international air arrivals and 93% of land arrivals.
The Alberta pilot study, and Ontario and New Brunswick voluntary truck drivers pilot projects are the main sources
of evidence of COVID-19 testing regarding exempt workers in Canada:
Preliminary results from the Alberta pilot study included 1,010 exempt travellers arriving by air and 144
arriving by land from November to December 2020 with a test positivity rate of 2.5% and 1.4%,
respectively.
In the Ontario Voluntary Truck Drivers Pilot Project, 918 exempt cross-border truck drivers were tested
from July to September 2020, finding zero cases.
In the New Brunswick Truck Driver Pilot Project, 1,199 truck drivers were tested from May to August
2020, also finding zero cases.
In the Alberta pilot study, it’s difficult to determine whether the test positivity found in exempt workers is due to
their status, the type of border crossing or the country of origin (mostly the United States). The results from all 3
studies appear to be at odds. However, they were conducted over different timeframes and with different
epidemiology. The truck driver pilots were undertaken in the late spring and summer, when the incidence of
COVID-19 was much lower in Canada and the US, than over the winter. It’s also possible that there are provincial
differences in the risk of infection for exempt workers. The results of these pilots raise the question as to whether
some measures should also apply to exempt workers.
Stakeholder groups representing exempt travellers, with whom the Panel consulted, indicated that if testing
requirements are imposed on essential workers based on the rationale that they are a higher-risk group, they
should also be prioritized for vaccination.
Canadian example
British Columbia: For agricultural temporary foreign workers, the British Columbia government is funding
quarantine at government-funded hotels. It’s also funding cost for food service, laundry services, interpretation
and translation services, health screening and other necessary services. This program appears to have been
successful. All 64 COVID-19 positive cases were detected in 4,997 workers from April and December 31, 2020.
Everyone recovered under the care and supervision of the program, with no known transmission into the
community.
Onward travellers
“Onward travellers” are those who arrive from an international airport and board an airplane, train or bus to their
final location. According to internal PHAC modeling, there is a negligible marginal benefit to additional testing for
onward travellers with a RAT when a pre-departure PCR test has been conducted. If there’s a 1.2% positivity rate
among travellers, adding an antigen test will detect only another 9 cases for every 10,000 travellers, because most
cases will already have been detected by PCR. As well, this approach requires a significant increase in testing
capacity at airports, which could result in crowded conditions during peak travel times and thus lead to increased
| 11
Priority strategies to optimize testing and quarantine at Canada’s borders
risk of transmission. Traveller test registration, swabbing, wait times, recording and referral times would result in a
wait of up to 45 minutes.
International example
Iceland: In Iceland, travellers must present a negative PCR test within 72 hours of departure. If passengers are
connecting, the 72 hours are counted from when the passenger boards their first flight. They are asked for proof
of boarding and the test result.
Vaccinated travellers
As of March 2021, COVID-19 vaccine efficacy data are only available for a few months following vaccination. For 2-
dose COVID-19 vaccines, the highest efficacy is seen after 2 doses. Currently, authorized vaccines in Canada are
moderately to highly efficacious in preventing symptomatic COVID-19 and highly efficacious in preventing severe
disease. Many experts have expressed views that vaccination is very likely to reduce the risk of infection and
transmission of SARS-CoV-2. Evidence to support this view is starting to accumulate.
Clinical trials and real-world effectiveness studies have demonstrated that all COVID-19 vaccines available in
Canada are effective against SARS-CoV-2 infection and highly effective against severe disease.
28
,
29
,
30
,
31
,
32
,
33
,
34
,
35
,
36
,
37
,
38
,
39
There is also evidence that people with a previous infection have reduced risk of re-infection, at least
temporarily.
40
,
41
,
42
,
43
Randomized controlled trials and observational studies suggest that COVID-19 vaccination
reduces viral load, which has been linked to reduced transmission in a small observational study.
44
,
45
,
46
A cohort
study reported a 54% reduction in the hazard of documented COVID-19 infection among the household members
of health care workers who had received their full vaccine regimen. Furthermore, there’s also evidence that
vaccination prevents asymptomatic disease.
47
,
48
,
49
Overall, these studies suggest that vaccination reduces the risk
of transmission of COVID-19.
There is also uncertainty about the effectiveness, duration of protection and reduction in transmission risk after a
single dose of 2-dose vaccines. Re-analysis of phase 3 trial data for the Pfizer-BioNTech and Moderna vaccines
suggested efficacies of 89% and 95%, respectively, about 2 weeks after the first dose.
50
,
51
,
52
Since then, real-world
studies have found single-dose effectiveness ranging from 46% to 80% against SARS-CoV-2 infection and
symptomatic infection.
53
,
54
,
55
,
56
,
57
,
58
Some of this variability may be due to differences in the time elapsed since
the dose.
59
,
60
A study from the U.S. Centers for Disease Control and Prevention (CDC) shows that both 1 and 2 doses of the
authorized 2-dose mRNA COVID-19 vaccines provided early, substantial protection against infection for health care
personnel, first responders and other frontline essential workers. Another observational study reported that first
dose effectiveness in adults ages 70 and older plateaued 28 to 34 days after the first dose, at 60% to 70%. There
have also been reports of reduced viral load in those infected after receiving only one dose. Finally, a 30%
reduction in hazard of documented COVID-19 infection was reported among household members of health care
workers who had been vaccinated. Of these, 78.3% had only received 1 dose.
While more evidence is needed, a single dose of a 2-dose vaccine appears to confer substantial protection in most
recipients for some period of time. In most recipients, the second dose of a 2-dose vaccine likely confers some
additional protection and extends the duration of protection.
People previously infected with SARS-CoV-2 have been found to have persistent neutralizing antibodies and
immune memory for 5 to 8 months after infection.
61
,
62
Observational studies have found that those with evidence
of previous infection were 81% to 100% less likely to have future infections, at least within 5 to 7 months following
infection.
63
,
64
,
65
,
66
,
67
Outbreak and close contact investigations have also found that those with previous infections
12 |
Priority strategies to optimize testing and quarantine at Canada’s borders
were strongly protected against re-infection.
68
,
69
Together, this suggests a protective effect against future infection
in those with a previous infection.
No direct evidence about transmission risk in people with previous infections was found. Updated guidance from
the CDC states that people previously infected with COVID-19 within 3 months of travel are not required to
undergo pre-departure testing.
Figure 2: CDC and international travel during COVID-19
Overall, travellers who have been vaccinated or previously infected likely pose a lower risk of importation and
transmission of SARS-CoV-2. However, some COVID-19 vaccines may have reduced effectiveness against existing
and emerging VoCs.
70
,
71
,
72
,
73
,
74
,
75
,
76
Therefore, border measures for vaccinated travellers need to be evaluated
carefully as new evidence continues to emerge. The approach taken towards testing and quarantine for vaccinated
travellers must weigh the evidence on potentially reduced overall infection and transmission risk against the
burden of mandatory testing and quarantine requirements on people.
Some countries have opted to reduce or eliminate quarantine requirements for fully vaccinated people (14 days
after the second vaccine dose). Greece, Poland, Mumbai and some US states (Massachusetts and Vermont) have
removed travel quarantine requirements, while Thailand has opted to reduce travel quarantine from 14 to 7
days.
77
,
78
,
79
,
80
,
81
,
82
Belize has eliminated testing requirements for travellers who are fully vaccinated. Iceland will
waive requirements for negative PCR tests, border screening and quarantine for anyone who provides
| 13
Priority strategies to optimize testing and quarantine at Canada’s borders
documentation that they have been fully vaccinated. The European Union is proposing a Digital Green Certificate,
which will provide information on whether a traveller has been vaccinated, has recovered from COVID-19, and if
not, the result of their COVID-19 tests.
Some countries are taking more conservative approaches. China will still require quarantine and testing of
travellers, irrespective of vaccination status. Australia still requires 14-day mandatory quarantines for those
outside of the safe zone (New Zealand), but will waive requirements of pre-departure tests for fully vaccinated
people.
The CDC recently released updated recommendations for vaccinated travellers noting that they are less likely to
get and spread COVID-19. The CDC does recommend that vaccinated travellers continue to follow its
recommendations for safe travel including, for example, wearing a mask and washing hands often. The CDC
recommends that both vaccinated and unvaccinated travellers present a negative COVID test taken no more than
3 days pre-departure as well as a test 3 to 5 days after arrival. There is no quarantine required for vaccinated
travellers arriving in the US. A summary of the updated guidance from the CDC is included in Figure 2.
| 15
Priority strategies to optimize testing and quarantine at Canada’s borders
Recommendations
Our recommendations for testing related to travel at land and air border crossings and quarantine, are based on
the evidence available to us when this report was written. As additional data and evidence become available, these
recommendations may need to be revisited.
The Panel considered 3 broad principles in developing its recommendations.
Border measures must evolve to reflect the experience gained and the
global situation regarding VoCs and vaccination
VoCs will affect the stringency of measures needed at the border. For existing and new SARS-CoV-2 variants, clear
evidence may arise of significantly decreased vaccine effectiveness, evasion of test detection, reduced
susceptibility to therapeutics and/or more severe disease. Arrival testing of vaccinated travellers is an important
component of surveillance for variants with reduced vaccine effectiveness. Finally, emerging evidence on the
effectiveness of COVID-19 vaccines in reducing transmission, including across different vaccine types and with 1 or
2 doses, will need to be considered when the recommendations are revisited.
The Panel recommends that the Government of Canada continue screening positive cases in international
travellers for VoCs. This screening will provide a surveillance tool to monitor for novel or emerging VoCs.
Additional short-term measures may be necessary as and when new emerging VoCs are identified in Canada or
internationally. These should be similar to what has been done at the border at various points throughout the
pandemic. This approach can help to reduce the risks of importation of a new or emerging VoCs into Canada. It
also allows time to adjust testing and quarantine measures on a general basis, recognizing that by the time a VoC is
detected in Canada, it is likely present in many countries.
The Panel recommends that the Government of Canada have procedures in place to ensure that all travellers
submit required tests and that all positive results are immediately communicated to the appropriate local public
health authority.
Border measures must be simple, easy to understand, equitable and
consider both benefits and harms
Canadians are more likely to adhere to border restrictions if they are clear, understandable, equitable and if they
avoid creating unreasonable delays and imposing unreasonable costs.
The Panel recommends that land and air border measures should be consistent as much as possible. The Panel’s
approach aims to promote the public good by recommending border measures that reduce the risk from SARS-
CoV-2 and its VoCs, while also not imposing excessive burdens on travellers, particularly exempt travellers.
The Panel recommends that the requirement for all air travellers to quarantine in government-authorized
accommodations be discontinued. However, travellers subject to quarantine must provide a suitable quarantine
plan for approval and adhere to this plan. The Panel recommends that the government continue to ensure that
those who do not have a suitable quarantine plan be required to adhere to an alternative one (for example, in
designated quarantine facilities). The country is in the third wave of COVID-19. This must be taken into
consideration when phasing out current border measures such as government-authorized accommodations.
16 |
Priority strategies to optimize testing and quarantine at Canada’s borders
The global nature of travel and human mobility means that country-specific travel restrictions are likely to be of
limited value. This is partially because travellers are able to circumvent such restrictions. As well, by the time such
restrictions are implemented, the relevant variant will likely have already spread to other countries. Therefore, the
Panel does not recommend implementation of country-specific testing or quarantine requirements at this time,
except under unique circumstances. Increased monitoring of quarantine compliance should be considered for
travellers arriving from countries with new variants of concern.
Rapid antigen tests were considered for onward travellers arriving by air as a means of quickly determining if they
were potentially positive. However, the Panel does not currently see substantial incremental value in testing
onward travellers at airports considering the other testing points throughout the traveller’s journey. If onward
travellers are transiting to an international flight, no arrival testing is required in Canada. If they are transiting to a
domestic flight or other transport, a PCR test is required on arrival.
Changes to border measures should be implemented in a phased
approach
The Panel heard from industry associations, unions and individual organizations (for example, airlines and airports)
on the importance of measures that can be phased in. Enough advance notice should be given to allow Canadians
and industry to prepare and plan accordingly. Future changes to border measures (for example, easing of
measures as vaccination becomes widespread) should be similarly phased. The Panel recommends phased
implementation of new border measures and consideration for the implementation process, including
enforcement, which for some new measures, may take more time to implement.
The Panel proposes a number of immediate measures for unvaccinated, partially vaccinated, vaccinated,
previously infected and exempt travellers (see Table 1). These recommendations will need monitoring and
adjusting as additional data and evidence continues to come in.
The Panel recommends the Government of Canada continue to use the ArriveCAN app to manage traveller
information reporting. The Panel also recommend that quarantine plans be reviewed and approved for
travellers arriving at both land and air borders, including symptom screening for all travellers. The Panel also
acknowledges that there will be a number of considerations regarding vaccine “certification.” A system to
validate proof of vaccination for arriving travellers should be made available as soon as possible.
The Panel proposes a focus on emerging evidence in the ongoing implementation and revision of border measures
for vaccinated travellers:
effectiveness of vaccines in reducing COVID-19 transmission
effectiveness of vaccines against VoCs and the prevention of their transmission
effectiveness for “partially” vaccinated travellers (those who have received 1 dose of a 2-dose vaccine)
SARS-CoV-2 and VoC importation among vaccinated travellers using border surveillance data
The Panel notes that while an evolution towards a consistent approach is recommended, travellers may be
required to follow additional provincial and territorial requirements or restrictions. For example, Nova Scotia
currently requires travellers outside of the Atlantic bubble (New Brunswick, PEI, Nova Scotia, Newfoundland and
Labrador) to self-isolate for 14 days when arriving in or returning to Nova Scotia.
In designing and deploying border measures that are intended to minimize risks, adherence to public health
measures during the continued roll-out of vaccines remains critical. The unintended consequences, including
impacts on compliance, associated with lower stringency measures for those already vaccinated must also be
considered, as vaccination prioritization strategies may cause age-based differences in the ability to travel at the
| 17
Priority strategies to optimize testing and quarantine at Canada’s borders
moment. The Panel recommends that all travellers follow requirements from public health authorities (including
physical distancing, mask wearing).
Figure 3: Summary of border measure recommendations
Table 1: Key air and land border measure recommendations for persons entering Canada
Group
Unvaccinated
non-exempt
traveller
18 |
Priority strategies to optimize testing and quarantine at Canada’s borders
Partially
vaccinated non-
exempt
travellers
(received a
single dose of a
2-dose vaccine
within the
maximum
recommended
2-dose interval
period)
Fully vaccinated
non-exempt
travellers
| 19
Priority strategies to optimize testing and quarantine at Canada’s borders
Travellers with
proof of
previous
infection in last
14 to 180 days
Exempt
travellers
20 |
Priority strategies to optimize testing and quarantine at Canada’s borders
| 21
Priority strategies to optimize testing and quarantine at Canada’s borders
Implementation considerations
Surveillance system characteristics
Ongoing evidence review and communication between Canada and its international partners will be essential in
maintaining a strong border testing program. Federal and provincial/territorial public health authorities should
collaborate closely to identify details of the travel history of positive travellers, particularly those with VoCs. This
will help to identify and adapt to new variants and vaccine effectiveness in a timely fashion.
Efforts to keep lab test and sequencing turnaround times as rapid as possible and consistent with national and
provincial standards should be ongoing. This will maximize the timeliness of surveillance testing information and
allow public health case and contact management to respond rapidly.
Voluntary testing in exempt travellers is mainly for surveillance purposes. It also may provide information that
informs further recommendations for exempt travellers.
Border logistics
Despite dramatic decreases in traveller volumes as a result of the pandemic (up to 90% reductions from pre-
pandemic travel), some airports and land borders may not be able to manage additional on-site COVID-19 testing.
An increase in travel will impact the number of people congregating in an airport. If travel increases in the coming
months, it will pose a greater burden on arrival testing and lab capacity, particularly for unvaccinated non-exempt
travellers. Similarly, even if only a small number of travellers are infected with SARS-CoV-2 and initiate new chains
of transmission, the absolute number of new chains of transmission will increase as the number of unvaccinated
non-exempt travellers increases. Managing the increased number of travellers on arrival is best solved through
frequent review of data and continuous improvement in the nature and application of border measures. These
measures must be responsive to and anticipate changes in risk based on evolving evidence.
Larger airports are experts in logistics and should be able to scale up to accommodate larger volumes. However,
they will need advance notice to prepare. The more advance the notice, the more prepared they will be. Smaller
airports may face more challenges. It will be important that all logistical elements, including adequate resources
and scaling, are in place to ensure safe and effective movement of travellers, as well as effective communications
about testing and quarantine.
Land border crossings will need to be reviewed to ensure they can scale up to effectively manage higher volumes
and testing requirements, even if only to provide ‘take-home’ sampling kits.
Quarantine and testing capacity
Changes in border measures over the coming months will eventually lead to an increase in the number of
travellers entering and departing the country. Implementation of ongoing arrival and day 7 testing of travellers will
require additional capacity to support testing processes, telephone support and quarantine compliance
verification.
New testing tools
As new testing tools become available, Canada should explore how they can be used to improve border measures.
For example, rapid tests that also screen for VoCs could increase the speed of testing as well as the speed for
managing cases and contact tracing. Similarly, emerging evidence on the effectiveness of unsupervised home
22 |
Priority strategies to optimize testing and quarantine at Canada’s borders
sampling could help relieve current logistical constraints. If adopted, further consideration is required to ensure
appropriate reporting to relevant public health authorities. As well, implementation of new testing tools will
require guidance to assist border agents will require support whenever new testing tools are implemented.
Digital technology
Data collection and management provides decision-makers with the necessary timely information needed to
respond during the pandemic. Data on the vaccinated population and the presence of VoCs can inform future
border measures. ArriveCAN is an important first step in the adoption of digital technology. However, maximizing
further use of existing and rapidly evolving digital technology to support border measures is also key (for example,
use of artificial intelligence in Greece).
The Panel strongly encourages further exploration of digital technology that can be used to gather data for
vaccinated populations and to improve quarantine effectiveness and compliance.
Communication
Along with border measures, travellers’ actions (for example, compliance with measures) once they enter Canada
will be a key contributor to minimizing the risk of secondary transmission of SARS-CoV-2.
The Panel recommends providing simple and clear information to travellers at the border about what they need
to do and about their risk of infecting others while in quarantine. Communicating this information will help
travellers make decisions to minimize the risk they may pose to others.
Further evolution of border measures
As new evidence about vaccination and variants of concern emerges, border measures will need to evolve. The
Panel offers the following criteria that may be used to decide when to reduce border measures:
there’s a high vaccination rate, particularly in high-risk settings and populations at high risk of mortality
and morbidity (for example, older than 50)
evidence supports herd immunity: the risk associated with specific recognized VoCs has been considered
and found acceptable (for example, vaccines have been shown to be effective for recognized VoCs)
surveillance capacity is maintained among travellers for existing and new VoCs across traveller groups
| 23
Priority strategies to optimize testing and quarantine at Canada’s borders
Conclusion
Border measures are essential to reduce the importation of SARS-CoV-2 and variants of concern into Canada. As
vaccines continue to roll out in Canada and internationally, it is an opportune time to examine how border
measures can be adjusted to continue to mitigate pandemic risks through testing and surveillance. Managing a
border is inherently complex but the measures in place must be easy to understand, equitable, feasible and
consider both benefits and harms. The proposed approach is evidence-informed and reflects the global situation
on SARS-CoV-2, VoCs and vaccine effectiveness.
The Panel identified 5 distinct groups of travellers for its border recommendations (unvaccinated, partially
vaccinated, fully vaccinated, previously infected and exempt travellers).
We present our recommendations to the Minister of Health for consideration in developing the federal
government’s approach to future border measures during the pandemic. Any changes to border measures will
likely need to be phased in to give enough time to adjust processes, logistics and communications.
| 25
Priority strategies to optimize testing and quarantine at Canada’s borders
Annex A: Summary of current border measures for persons
entering Canada
Table A-1: Border measures for persons entering Canada as of April 2021
Current measures
Land
Air
ArriveCan
completion
Required
Required
Pre-departure
testing
Ages 5+ must provide proof of a negative
COVID-19 molecular test taken up to 72
hours before arrival in Canada (must be
taken in US)
Ages 5+ must provide proof of a negative COVID-19
molecular test taken up to 72 hours before their
departure
Arrival testing
Take a molecular test for COVID-19 on
arrival
Molecular test before departure from the airport
Follow-up testing
Take an additional PCR test at day 10 of
their 14-day quarantine (provided with
test kit and instructions at border)
Take an additional PCR test on day 10 of the
mandatory quarantine (provided with test kit and
instructions before leaving airport)
Quarantine
Mandatory 14-day quarantine with check-
ins from public health authorities
Mandatory 14-day quarantine including up to 3-day
hotel quarantine at their cost upon arrival until
negative COVID-19 test is received
Note: marine entry is restricted at this time
| 27
Priority strategies to optimize testing and quarantine at Canada’s borders
Annex B: Exempt travelers
Travellers may be exempt from quarantine, pre-entry testing and/or arrival testing. Many of those who are
exempt from either testing or quarantine are exempt for essential reasons. However, those exempt from federal
quarantine or testing must still adhere to provincial and territorial restrictions.
Table B-1: Summary of border measure exemptions
Quarantine exemptions
Pre-testing exemptions
Arrival testing exemptions
Those exempt from quarantine
include those who:
Provide essential services
Maintain the flow of
essential goods or people
Are receiving medical care
within 36 hours of entering
Canada
Regularly cross the border to
work
Live in integrated trans-
border communities
Essential reasons for quarantine
exemption include:
Those in the medical and
health care field
Essential work as defined
under Emergency Orders
(includes persons in the
trade or transportation
sector, emergency service
providers and technicians or
specialists who support
critical infrastructure)
Those within trans-border,
remote cross-border or
geographically restricted
communities
Cross-border students and
people driving them
Cross-border custody
arrangements
Other special circumstances
Those exempt from pre-entry tests
include those who:
Have a resolved COVID-19
infection (positive COVID-19
test taken between 14 and
90 days before travel)
Are children under 5 years
of age
Are transiting through
Canada
Are receiving medical
treatments
Require medical evacuation
Essential work as defined
under Emergency Orders
(includes persons in the
trade or transportation
sector, emergency service
providers, and technicians or
specialists who support
critical infrastructure)
Other special circumstances
Those exempt from arrival testing
include those who:
Have a resolved COVID-19
infection (positive COVID-19
test taken between 14 and
90 days before travel)
Are children under 5 years
of age
Have diplomatic, official,
and courtesy visas
Require medical evacuation
Are traveling for national
interest reasons as
determined by the Minister
of Health
Are exempt from quarantine
requirements
| 29
Priority strategies to optimize testing and quarantine at Canada’s borders
References
1
Reducing travel-related SARS-CoV-2 transmission with layered mitigation measures: Symptom monitoring,
quarantine, and testing
2
Effectiveness of quarantine and testing to prevent COVID-19 transmission from arriving travelers
3
Reducing travel-related SARS-CoV-2 transmission with layered mitigation measures: Symptom monitoring,
quarantine, and testing
4
Routine asymptomatic testing strategies for airline travel during the COVID-19 pandemic: a simulation study
5
Strategies to reduce the risk of SARS-CoV-2 reintroduction from international travellers
6
Testing and cross-border risk management measures manual
7
Reducing travel-related SARS-CoV-2 transmission with layered mitigation measures: Symptom monitoring,
quarantine, and testing
8
Routine asymptomatic testing strategies for airline travel during the COVID-19 pandemic: a simulation study
9
Screening for SARS-CoV-2 infection in asymptomatic individuals using the Panbio™ COVID-19 Antigen Rapid Test
(Abbott) compared to RT-qPCR
10
Evaluation of the Panbio COVID-19 rapid antigen detection test device for the screening of patients with COVID-
19
11
Nasopharyngeal Panbio COVID-19 antigen performed at point-of-care has a high sensitivity in symptomatic and
asymptomatic patients with higher risk for transmission and older age
12
Panbio antigen rapid test is reliable to diagnose SARS-CoV-2 infection in the first 7 days after the onset of
symptoms
13
Requirement for proof of negative COVID-19 test or recovery from COVID-19 for all air passengers arriving in the
United States
14
Health Alert: Haiti, COVID Entry Requirement
15
COVID-19 in Jamaica
16
Coronavirus (COVID-19)
17
Coronavirus: Entering Switzerland
18
Entry rules, quarantine regimes, FAQ
19
COVID-19 travel requirements
20
COVID-19 International Border Surveillance Cohort Study at Toronto’s Pearson Airport
21
Optimal COVID-19 quarantine and testing strategies
22
Optimal COVID-19 quarantine and testing strategies
23
Strategies at points of entry to reduce importation risk of COVID-19 cases and reopen travel
24
Arriving in the NWT
25
COVID-19 (Coronavirus) Updates
26
Maximising public adherence to COVID-19 self-isolation in Europe
27
How can we improve self-isolation and quarantine for COVID-19?
28
Vaccines and Related Biological Products Advisory Committee Meeting Presentation
29
Vaccines and Related Biological Products Advisory Committee Briefing Document
30
Vaccines and Related Biological Products Advisory Committee Meeting
31
Vaccines and Related Biological Products Advisory Committee Meeting Presentation
32
Sponsor Briefing Document Addendum
33
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 VOC 202012/01 (B.1.1.7)
34
FDA-authorized COVID-19 vaccines are effective per real-world evidence synthesized across a multi-state health
system
35
Effectiveness of BNT162b2 mRNA vaccine against infection and COVID-19 vaccine coverage in healthcare
workers in England, Multicentre Prospective Cohort Study (the SIREN Study)
30 |
Priority strategies to optimize testing and quarantine at Canada’s borders
36
Early effectiveness of COVID-19 vaccination with BNT162b2 mRNA vaccine and ChAdOx1 adenovirus vector
vaccine on symptomatic disease, hospitalisations and mortality in older adults in England
37
BNT162b2 mRNA COVID-19 vaccine in a nationwide mass vaccination setting
38
Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine
39
Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine
40
Antibody status and incidence of SARS-CoV-2 infection in health care workers
41
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
42
Functional SARS-CoV-2-specific immune memory persists after mild COVID-19
43
Orthogonal SARS-CoV-2 serological assays enable surveillance of low-prevalence communities and reveal
durable humoral immunity
44
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 VOC 202012/01 (B.1.1.7)
45
Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine
46
Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study
47
BNT162b2 mRNA COVID-19 vaccine in a nationwide mass vaccination setting
48
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 VOC 202012/01 (B.1.1.7)
49
Interim estimates of vaccine effectiveness of BNT162b2 and mRNA-1273 COVID-19 vaccines
50
Annex A: Report to JCVI on estimated efficacy of a single dose of Pfizer BioNTech (BNT162b2 mRNA) vaccine and
of a single dose of ChAdOx1 vaccine (AZD1222)
51
Strategy for vaccination against COVID-19: Postponement of the second dose in a context of shortage
52
Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine
53
Effectiveness of BNT162b2 mRNA vaccine against infection and COVID-19 vaccine coverage in healthcare
workers in England, Multicentre Prospective Cohort Study (the SIREN Study)
54
Early effectiveness of COVID-19 vaccination with BNT162b2 mRNA vaccine and ChAdOx1 adenovirus vector
vaccine on symptomatic disease, hospitalisations and mortality in older adults in England
55
BNT162b2 mRNA COVID-19 vaccine in a nationwide mass vaccination setting
56
The effectiveness of the first dose of BNT162b2 vaccine in reducing SARS-CoV-2 infection 13-24 days after
immunization: real-world evidence
57
Early findings show the first vaccine dose reduced the risk of COVID-19 by 80 per cent or more
58
Interim estimates of vaccine effectiveness of BNT162b2 and mRNA-1273 COVID-19 vaccines
59
Annex A: Report to JCVI on estimated efficacy of a single dose of Pfizer BioNTech (BNT162b2 mRNA) vaccine and
of a single dose of ChAdOx1 vaccine (AZD1222)
60
Strategy for vaccination against COVID-19: Postponement of the second dose in a context of shortage
61
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
62
Orthogonal SARS-CoV-2 serological assays enable surveillance of low-prevalence communities and reveal
durable humoral immunity
63
Antibody status and incidence of SARS-CoV-2 infection in health care workers
64
SARS-CoV-2 reinfection in a cohort of 43,000 antibody-positive individuals followed for up to 35 weeks
65
Prior SARS-CoV-2 infection is associated with protection against symptomatic reinfection
66
Real-world data suggest antibody positivity to SARS-CoV-2 is associated with a decreased risk of future infection
67
Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in
Denmark in 2020: a population-level observational study
68
COVID-19 Outbreak at an Overnight Summer School Retreat ― Wisconsin, JulyAugust 2020
69
Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October
2020
70
Science Brief: Background rationale and evidence for public health recommendations for fully vaccinated people
71
Effectiveness of BNT162b2 mRNA vaccine against infection and COVID-19 vaccine coverage in healthcare
workers in England, Multicentre Prospective Cohort Study (the SIREN Study)
72
Early effectiveness of COVID-19 vaccination with BNT162b2 mRNA vaccine and ChAdOx1 adenovirus vector
vaccine on symptomatic disease, hospitalisations and mortality in older adults in England
73
BNT162b2 mRNA COVID-19 vaccine in a nationwide mass vaccination setting
| 31
Priority strategies to optimize testing and quarantine at Canada’s borders
74
Sponsor Briefing Document Addendum
75
Vaccines and Related Biological Products Advisory Committee Meeting
76
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
77
Greece to eliminate quarantine rule for travelers ahead of May reopening
78
Poland lifts quarantine requirement for fully vaccinated travelers from select countries
79
Mumbai: International travellers can now skip quarantine if fully vaccinated
80
COVID-19 Travel Advisory
81
Visitors to Vermont
82
Thailand to reduce quarantine period for vaccinated travellers